Obama keeps faith in science and warns of cyber threats

Peter Aldhous, San Francisco bureau chief

"IT IS our unfinished task to restore the basic bargain that built this country - the idea that if you work hard and meet your responsibilities, you can get ahead."

In adopting the phrase "unfinished task" as a signature motif for his 2013 State of the Union address, President Barack Obama signalled a return to familiar themes. For those who care about investment in science, that was a reassuring message. 

The fight against global warming and the importance of technology to protect national security also got high billing. On the latter, Obama signaled that hacking skills, rather than kilotons, are increasingly a crucial currency, promising a new focus on combating cyberattacks - paralleled by negotiated cuts to the US nuclear arsenal. 

In a combative speech designed to counter Republican opponents who want to cut the budget deficit by curbing spending on Obama's priorities - including education and research - the President made the case for continued investment in innovation.

"Every dollar we invested to map the human genome returned $140 to our economy. Today, our scientists are mapping the human brain to unlock the answers to Alzheimer's; developing drugs to regenerate damaged organs; devising new material to make batteries ten times more powerful. Now is not the time to gut these job-creating investments in science and innovation. Now is the time to reach a level of research and development not seen since the height of the Space Race."

The estimate of a 140:1 return on investment in genomics comes from a 2011 study by the Battelle Memorial Institute in Columbus, Ohio. While the precise numbers from that analysis have been questioned, the importance of continued innovation to America's future economic competitiveness has been stressed in multiple reports, notably from the US National Academies. 

"Now our enemies are also seeking the ability to sabotage our power grid, our financial institutions, and our air traffic control systems. We cannot look back years from now and wonder why we did nothing in the face of real threats to our security and our economy."

Obama called on Congress to pass new legislation to counter threats from hackers backed by hostile governments. That won't be easy: last year, a bill that would have demanded that companies meet minimum standards for cybersecurity, and report if they are attacked, foundered amid complaints that it would impose large costs on US businesses. 

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Pope makes first appearance since shock resignation

VATICAN CITY: Pope Benedict XVI made his first public appearance Wednesday since the shock announcement of his resignation, sticking with his schedule by presiding over his weekly general audience.

Tickets to the event in the Vatican's Paul VI auditorium were issued well in advance, so several thousand pilgrims experienced the historic moment out of sheer luck just two days after the 85-year-old Benedict said he would step down at the end of the month.

The pope will then celebrate Ash Wednesday mass at 1600 GMT, his last public mass and one of his final engagements as pontiff.

The mass is traditionally held in the Santa Sabina Church on Rome's Aventine Hill, but has been moved to St Peter's Basilica out of respect for the outgoing pontiff and to accommodate the crowd of faithful who will want to mark the end of his eight-year rule -- one of the shortest in the Church's modern history.

"It will be an important concelebration, and the last led by the Holy Father in Saint Peter's," Vatican spokesman Federico Lombardi said.

The high point of Wednesday's mass, which launches the traditional period of penitence ahead of Easter in the Christian calendar, will see the pope mark the foreheads of the faithful with ashes.

Lombardi has said he expects a new pope in place in time for Easter, which falls on March 31 this year, although no date has yet been set for the secret conclave to elect a new leader of the world's 1.2 billion Catholics.

In the meantime, the outgoing pontiff will honour his existing engagements.

On Thursday he will hold his annual meeting with the pastors of Rome. And before he steps down at the end of the month he will also meet the presidents of Guatemala and Romania, as scheduled.

Next week will be given over to a spiritual retreat at the Vatican which is sure to be dominated by jockeying among factions within the College of Cardinals over the choice of Benedict's successor.

Benedict's decision to step down -- making him the first pontiff in 700 years to resign simply because he cannot carry on -- sparked a flurry of rumours over his health, fed by revelations that he had had an operation to replace the batteries in his pacemaker three months ago.

Some observers saw Benedict's decision as a bid to avoid the fate of his predecessor John Paul II, whose drawn-out and debilitating illness was played out on the world's stage.

But Lombardi insisted: "The pope is well and his soul is serene.

"He did not resign the pontificate because he is ill but because of the fragility that comes with old age."

After Ash Wednesday Benedict will, on the next two Sundays, will recite the Angelus from his apartment window and hold his final general audience, this time in St. Peter's Square on February 27, before retiring to a little-known monastery within Vatican walls.

Soon a new pope will be installed in the papal apartments, with his predecessor just a stone's throw away.

But Benedict will spend his time in prayer rather than giving advice, the Vatican says.

As rumours fly over front-runners for St. Peter's chair, commentators have said age may be a key factor in selecting a new pope, although any of the 117 cardinals eligible to vote is likely to be chosen.

While some hope Africa or Asia could yield the next pontiff, others have tipped high-flying European or North American cardinals. The new pope will have to face up to the growing secularism in the West, one of the Church's biggest challenges.

Only one other pope has resigned because of an inability to carry on -- Celestine V in 1294 -- a humble hermit who stepped down after just a few months saying he could no longer bear the intrigue of Rome.

-AFP/fl

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Not surprisingly, House GOP pans State of the Union

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Obama: Both parties know sequester cuts "a really bad idea"

It shouldn't come as a shock that congressional Republicans weren't very impressed by President Obama's State of the Union address. 

For his part, the president didn't hide his suggestion that it's Republicans who are resistant to compromise, leading some Republicans to jab the president, particularly regarding his lack of clarity on how he would replace the so-called sequester cuts set to slash defense and domestic spending on March 1.

"What has he done?" asked Rep. Cory Gardner, R-Colo. "He signed the sequester, he agreed to the sequester, he came up with the sequester and then he complains about House solutions to actually try to deal with it. This president is more interested in campaign-style rhetoric than actual solutions."

While many said there is some room to work with Mr. Obama on issues like immigration, and even some gun safety measures, his new proposals on everything from education to repairing the nation's crumbling bridges were panned not necessarily based on merit, but on the president's claim that the new programs would not increase the deficit "by a single dime."

"I think it doesn't pass the laugh test" said the chairman of the conservative House Republican Study group Rep. Steve Scalise, R-La. "People realize the President promised to cut the deficit in half and it's more than doubled."

"It's economic fairy dust that this President's working with," added Gardner.

On the president's call to address climate change and become more energy independent, Rep. Lee Terry, R-Neb., called the president's silence on giving the green light to construct the Keystone XL pipeline to pump oil from Canada to the Gulf of Mexico "deafening."

Chairman of the House Energy and Commerce Committee Fred Upton, R-Mich., also said "With a stroke of the pen, the president could unleash this $7 billion private sector investment. Yet nowhere in this evening's blueprint for the president's policy vision was this critical middle-class jobs project."

Rep. Raul Labrador, R-Idaho, who is expected to be a key House Republican player in immigration talks as a Hispanic-American from a conservative state, said the president's State of the Union this year was "one of the least inspiring speeches I ever heard him give."

But Labrador said he does think Republicans and Democrats will ultimately be able to come together on an overhaul of the nation's immigration system.

"As long as the president and his party don't draw a red line and say that they have to get everything that they want."

Labrador was less optimistic about gun control. He compared his home state of Idaho with low crime and few gun regulations to Mr. Obama's home state of Illinois as an example of why gun laws aren't necessarily effective.

"It has the most stringent gun control legislation and it has some of the highest crime in the United States" Labrador said of Illinois. "Clearly gun control is not going to protect those families."

And while Labrador said he believes the president cares about the victims of gun violence and their families that attended the speech, he said they should not be used as "political pawns."

Labrador said, however, that as a father of five children he was so upset by the Sandy Hook Elementary School massacre that he could not speak of the shooting for two days. He said "if there's things that we can do to save lives without violating the second amendment I think we should consider it."

Democrats gave the speech high marks. In a statement, Minority Leader Nancy Pelosi, D-Calif., said she urged the two parties to work together and said "it is time to heed the President's call for real progress to reverse the rising tide of climate change, enact comprehensive immigration reform, and prevent gun violence."

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Charred Human Remains Found in Burned Cabin

Investigators have located charred human remains in the burned out cabin where they believe suspected cop killer and ex-LAPD officer Christopher Dorner was holed up as the structure burned to the ground, police said.

The human remains were found within the debris of the burned cabin and identification will be attempted through forensic means, the San Bernardino County Sheriff-Coroner Department said in a press release early this morning.

Dorner barricaded himself in the cabin in the San Bernardino Mountains near Big Bear Tuesday afternoon after engaging in a gunfight with police, killing one officer and injuring another, the San Bernardino County Sheriff's Department said.

Cindy Bachman, spokeswoman for the San Bernardino County Sheriff's Department, which is the lead agency in the action, said Tuesday night investigators would remain at the site all night.

FULL COVERAGE: Christopher Dorner Manhunt

When Bachman was asked if police thought Dorner was in still in the burning cabin, she said, "Right… We believe that the person that barricaded himself inside the cabin engaged in gunfire with our deputies and other law enforcement officers is still inside there, even though the building burned."

Bachman spoke shortly after the Los Angeles Police Department denied earlier reports that a body was found in the cabin, contradicting what law enforcement sources told ABC News and other news organizations.

Christopher Dorner Manhunt: Police Exchange Fire With Possible Suspect Watch Video

Fugitive Ex-Cop Believed Barricaded in Cabin, California Cops Say Watch Video

Police around the cabin told ABC News they saw Dorner enter but never leave the building as it was consumed by flames, creating a billowing column of black smoke seen for miles.

A press conference is scheduled for later today in San Bernardino.

One sheriff's deputy was killed in a shootout with Dorner earlier Tuesday afternoon, believed to be his fourth and victim after killing an LAPD officer and two other people this month, including the daughter of a former police captain, and promising to kill many more in an online manifesto.

PHOTOS: Former LAPD Officer Suspected in Shootings

Cops said they heard a single gunshot go off from inside the cabin just as they began to see smoke and fire. Later they heard the sound of more gunshots, the sound of ammunition being ignited by the heat of the blaze, law enforcement officials said.

Police did not enter the building, but exchanged fire with Dorner and shot tear gas into the building.

One of the largest dragnets in recent history, which led police to follow clues across the West and into Mexico, apparently ended just miles from where Dorner's trail went cold last week.

Police got a break at 12:20 p.m. PT, when they received a 911 call that a suspect resembling Dorner had broken into a home in the Big Bear area, taken two hostages and stolen a car.

The two hostages, who were tied up by Dorner but later escaped, were evaluated by paramedics and were determined to be uninjured.

Officials say Dorner crashed the stolen vehicle and fled on foot to the cabin where he barricaded himself and exchanged fire with deputies from the San Bernardino Sheriff's Office and state Fish and Game officers.

Two deputies were wounded in the firefight and airlifted to a nearby hospital, where one died, police said. The second deputy was in surgery and was expected to survive, police said.

Police sealed all the roads into the area, preventing cars from entering the area and searching all of those on the way out. Are schools were briefly placed on lockdown.

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Arctic sunshine cranks up threat from greenhouse gases

IT'S a solar double whammy. Not only does sunlight melt Arctic ice, but it also speeds up the conversion of frozen organic matter into carbon dioxide.

The amount of carbon in dead vegetation preserved in the far northern permafrost is estimated to be twice what the atmosphere holds as CO₂. Global warming could allow this plant matter to decompose, releasing either CO₂ or methane – both greenhouse gases. The extent of the risk remains uncertain because the release mechanisms are not clear.

Rose Cory at the University of North Carolina at Chapel Hill and her colleagues analysed water from ponds forming on melting permafrost at 27 sites across the Arctic. They found that the amount of CO₂ released was 40 per cent higher when the water was exposed to ultraviolet light than when kept dark. This is because UV light, a component of sunlight, raises the respiration rate of soil bacteria and fungi, amplifying the amount of organic matter they break down and the amount of CO₂ released.

The thawing Arctic is emerging as a potentially major source of positive feedback that could accelerate global warming beyond existing projections. "Our task now is to quantify how fast this previously frozen carbon may be converted to CO₂, so that models can include the process," Cory says.

Journal reference: PNAS, DOI: 10.1073/pnas.1214104110.

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Shocked world media speculates on pope's successor

MANILA: The world's media speculated on whether the next pontiff may come from the developing world, while paying mixed tributes to Pope Benedict XVI following his shock resignation announcement.

The 85-year-old Benedict said on Monday that he would step down at the end of this month because of health reasons, becoming the first leader of the Catholic Church to resign of his own free will in 700 years.

Argentina's largest selling newspaper, Clarin, ran a headline on its website asking whether the next pope might hail from the Americas, Asia or Africa rather than Europe, where all popes have come from through the centuries.

"After the virtually unprecedented decision by the head of the church to resign, there is a growing possibility that deeply established traditions and criteria might change in the next choosing of the pope and there could be a surprise," the report said.

Clarin said this was not just a matter of geography but something that went much deeper.

Catholicism is in serious decline in Europe but growing robustly in Africa and Asia. And Latin America, despite fervent adherence to the faith being patchy, is home to 40 percent of the world's Catholics, the paper noted.

In the Philippines, the Catholic Church's stronghold in Asia, the pope's decision dominated the front pages of newspapers, while major Internet news sites focused on whether Filipino Cardinal Luis Antonio Tagle may succeed him.

"He has the rare chance, like 116 others, to choose the leader of the world's 1.2 billion Catholics. And who knows? He himself may become Pope Benedict XVI's successor," news portal Rappler wrote of Cardinal Tagle.

The pope's resignation made the front pages of most British newspapers, which largely praised his personal qualities, but they also called for the next pope, whether he is from Europe, Asia, Africa or the Americas, to bring about reform.

In an editorial, The Guardian said that Benedict's papacy was "theologically, politically and organisationally a continuation of that of John Paul II, with all its defects and its virtues".

It painted a sober picture of the future, saying that "not a single liberal candidate to succeed Benedict can be identified".

The Times described Benedict's resignation in an editorial as a "noble and selfless decision" but said his successor should try to make the Catholic church "a more collegial venture".

The Independent newspaper focused on the future with the headline "Situation Vacant: New leader wanted for 1.2 billion Roman Catholics".

It added that Benedict's announcement "plunges his Church into turmoil".

In France, daily Catholic newspaper La Croix praised Benedict for making a tough decision.

"This is a man of faith who has decided to resign with the consciousness of having given everything he could for the good of the Church," the newspaper said.

Conservative French newspaper Le Figaro published a special edition in which it welcomed the "humility" of Benedict XVI, who "felt that the challenges of the contemporary church exceeded its powers".

The pope's resignation also made the front pages in Australia, with Rupert Murdoch's national daily newspaper The Australian carrying a headline that said: "Pope Benedict surrenders: too old, too frail to lead a billion people".

In an opinion piece, the newspaper's foreign editor said Benedict was "a good man but a poor pope".

"Benedict was always going to have a hard time following in the footsteps of John Paul II, the most charismatic, and perhaps the most influential, pope in the 20th century," wrote Greg Sheridan.

"But he disappointed even his closest supporters."

- AFP/al

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North Korea says it conducted third nuclear test

STORY HIGHLIGHTS

• NEW: The test is "a significant step forward" for the North's program, an analysts says


• Obama calls the test "highly provocative," calls for "swift" international action


• North Korea confirms it carried out a more powerful test


• It says it used a smaller, lighter bomb than in previous tests

Hong Kong (CNN) -- North Korea said Tuesday that it had conducted a new, more powerful underground nuclear test using more sophisticated technology, jolting the already fragile security situation in Northeast Asia and drawing condemnation from around the globe.

It is the first nuclear test carried out under the North's young leader, Kim Jong Un, who appears to be sticking closely to his father's policy of building up the isolated state's military deterrent to keep its foes at bay, shrugging off the resulting international condemnation and sanctions.

It also provided a provocative reminder of a seemingly intractable foreign policy challenge for President Barack Obama ahead of his State of the Union address later Tuesday.

"The test was carried out as part of practical measures of counteraction to defend the country's security and sovereignty in the face of the ferocious hostile act of the U.S.," the North's state-run Korean Central News Agency (KCNA) said, referring to new U.S.-led sanctions on Pyongyang in the wake of a recent long-range rocket launch.

The nuclear test Tuesday, which follows previous detonations by the North in 2006 and 2009, had greater explosive force and involved the use of a smaller, lighter device, KCNA reported.

North Korea's nuclear program is shrouded in secrecy, so it's almost impossible to independently verify many of the details of the test. But its claims play into fears among the United States and its allies that Pyongyang is moving closer to the kind of miniaturized nuclear device that it can mount on a long-range missile.

Despite the North's claims of progress Tuesday, analysts say they believe it is still years away from having the technology to deliver a nuclear warhead on a missile.

"This test isn't going to do that in and of itself, but it is a significant step forward," said Mike Chinoy, a senior follow at the University of Southern California's U.S.-China Institute.

Condemnation from world leaders

After Pyongyang confirmed it had gone ahead with the test in defiance of international pressure, world leaders responded with condemnation.

"This is a highly provocative act" that threatens regional stability, breaches U.N. resolutions and increases the risk of proliferation, Obama said in a statement.

"North Korea's nuclear weapons and ballistic missile programs constitute a threat to U.S. national security and to international peace and security," he said. "The United States remains vigilant in the face of North Korean provocations and steadfast in our defense commitments to allies in the region."

Obama called for "further swift and credible action by the international community" in response to Pyongyang's actions.

"It is a clear and grave violation of the relevant Security Council resolutions," the office of Ban Ki-moon, the secretary-general of the United Nations, said in a statement referring to the test.

The United Nations Security Council will meet in New York on Tuesday morning to discuss the development, a security council diplomat said, declining to be identified because of U.N. protocol on such matters.

Japanese Prime Minister Shinzo Abe said the test was "extremely regrettable," adding that Tokyo would "strongly" protest it.

Seismic activity

U.S. seismologists reported a disturbance on Tuesday morning in North Korea centered near the site of the secretive regime's two previous atomic blasts.

The area around thepicenter of the tremor in northeastern North Korea has little or no history of earthquakes or natural seismic hazards, according to U.S. Geological Survey maps.

The disturbance reported Tuesday had a magnitude of 5.1 -- upgraded from an initial estimate of 4.9 -- took place at a depth of about 1 kilometer, the USGS said.

Kim Min-seok, a spokesman for the South Korean defense ministry, said the magnitude of the "artificial tremor" suggested the size of the blast could be in the order of 6 to 7 kilotons, more powerful than the North's two prior nuclear tests.

That calculation, though, was based on the USGS's initial estimate of a 4.9-magnitude seismic disturbance, he said. A 5.1-magnitude tremor could indicate a 10 kiloton explosion.

The China Earthquake Network Center said on its website that the seismic disturbance in North Korea was a "suspected explosion."

News breaks at a quiet time in Asia

The test took place at a time when several East Asian countries, including China, North Korea's major ally, are observing public holidays for the Lunar New Year, which began Sunday.

It also comes ahead of the birthday on Saturday of Kim Jong Il, the former North Korean leader who died in December 2011 and was succeeded by his son, Kim Jong Un.

North Korea announced last month that it was planning a new nuclear test and more long-range rocket launches, all of which it said were part of a new phase of confrontation with the United States.

It made the threats two days after the United Nations Security Council had approved the broadening of sanctions on the reclusive, Stalinist regime in response to the North's launching of a long-range rocket in December that succeeded in putting a satellite in orbit.

Pyongyang said it carried out the launch for peaceful purposes, but it was widely considered to be a test of ballistic missile technology.

U.S. analysts say North Korea's first bomb test, in October 2006, produced an explosive yield at less than 1 kiloton (1,000 tons) of TNT. A second test in May 2009 is believed to have been about two kilotons, National Intelligence Director James Clapper told a Senate committee in 2012.

By comparison, the bomb the United States dropped on Hiroshima in 1945 was a 15-kiloton device.

In May 2012, North Korea said it had amended its constitution to formally proclaim itself a "nuclear state."

CNN's Jethro Mullen reported and wrote from Hong Kong. CNN's K.J. Kwon in Seoul, South Korea; Yoko Wakatsuki and Junko Ogura in Tokyo; Judy Kwon in Hong Kong; Dana Ford and Matt Smith in Atlanta, Georgia; Anna Maja Rappard in New York; and Elise Labott in Washington contributed to this report. Journalists Katie Hunt in Hong Kong and Connie Young in Beijing also contributed reporting.

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State of the Union guests reflect nation's hot-button issues

Several lawmakers are bringing special guests to President Obama's State of the Union address Tuesday night in order to make a statement.

Several lawmakers are bringing guests to help underscore the importance of gun control. More than 20 House Democrats are bringing guests who have been personally affected by gun violence. A bipartisan pair of Arizona lawmakers, meanwhile, will host former Rep. Gabrielle Giffords, D-Ariz., and her husband Mark Kelly.

Other lawmakers are bringing guests tied to issues like immigration and voting rights.

Below is a partial list of officials and the guests they are bringing. CBS News will update the list as more guests are confirmed:

First Lady Michelle Obama:

• Lt. Brian Murphy, who was wounded while responding to the Sikh Temple shooting last August in Oak Creek, Wisconsin. He was struck by 15 bullets.
• Cleopatra Cowley-Pendleton and Nathaniel Pendleton Sr., parents of 15-year-old Hadiya who was killed in a Chicago park.
• Desiline Victor, a 103-year-old Florida woman who waited in line for several hours to vote.
• Tim Cook, CEO of Apple.

House Minority Leader Pelosi:

• Mother and daughter from Newtown, Conn. The 4th grader sent Pelosi a letter asking for her support to strengthen gun laws in the wake of the Sandy Hook massacre.

Sen. John McCain, R-Ariz., and Rep. Ron Barber, D-Ariz.:

• Former Rep. Gabrielle Giffords, D-Ariz., and her husband Mark Kelly

Rep. Steve Stockman, R-Texas:

• Musician and gun advocate Ted Nugent

Sens. Richard Blumenthal, D-Conn., and Chris Murphy, D-Conn.:

• First Selectwoman Pat Llodra, a Republican and the Chief Executive Officer of Newtown
• Newtown Detectives Jason Frank and Dan McAnaspie, two of several first responders who rushed to Sandy Hook Elementary School on the day of the tragedy

Rep. Luis Gutierrez, D-Ill.:

• Undocumented immigrant Gabino Sanchez. The South Carolina husband and father of two U.S. citizen children is fighting deportation. Sanchez entered the country when he was 15 years old and has been working and living peacefully in the U.S. ever since.

Sen. Dianne Feinstein, D-Calif.:

• Josh Stepakoff, who in 1999 was shot at the North Valley Jewish Community Center in Granada Hills, Calif. Stepakoff, now 20, is a student at California State University Northridge.

Sen. Frank Lautenberg, D-N.J.:

• Matt Gross, a New Jersey native who was shot in the head in 1997, at the age of 27. Gross was one of several victims wounded during a shooting attack on the observation deck of the Empire State Building.

More House Democrats bringing guests affected by gun violence:

Rep. Jim Langevin, R.I.

Rep. Keith Ellison, Minn.

Rep. Carolyn McCarthy, N.Y.

Rep. Rosa DeLauro, Conn.

Rep. David Cicilline, R.I.

Rep. Diana DeGette, Colo.

Rep. Tammy Duckworth, Ill.

Rep. Elizabeth Esty, Conn.

Rep. Lois Frankel, Fla.

Rep. Lujan Grisham, N.M.

Rep. Janice Hahn, Calif.

Rep. Jim Himes, Conn.

Rep. Alan Lowenthal, Calif.

Rep. Gloria Negrete-McLeod, Calif.

Rep. Eleanor Holmes Norton, D.C.

Rep. Ed Perlmutter, Colo.

Rep. Jan Schakowsky, Ill.

Rep. Brad Schneider, Ill.

Rep. Bobby Scott, Va.

Rep. Mike Thompson, Calif.

Rep. Krysten Sinema, Ariz.

Rep. Chris Van Hollen, Md.

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Why we're building a €1 billion model of a human brain

The Human Brain Project has just won a €1 billion research prize. Its director Henry Markram says the initiative will unify our understanding of the brain

Your project aims to recreate the human brain in a supercomputer. Why?
We want to reach a unified understanding of the brain and the simulation on a supercomputer is the tool. Today you have neuroscientists working on a genetic, behavioural or cognitive level, and then you have informaticians, chemists and mathematicians. They all have their own understanding of how the brain functions and is structured. How do you get them all around the same table? We think of the project as like a CERN for the brain. The model is our way of bringing everyone, and our understanding, together.

What do you hope will come of the project?
There are three goals. As the model becomes more accurate and behaves more like a brain, we could couple it to a robot and see the robot learning. Then we'll be able to trace the chain of events from molecules to cognition.

Second, we plan to collect data from hospitals around the world to search for biological signatures of disease. We believe this will give us a new classification of brain disease, which can be used to diagnose people objectively - not solely based on their symptoms.

And finally, we want to build neuromorphic computers, which would have processors that can learn, mimicking the way the brain does.

How close are you to recreating a brain?
We've developed an algorithm to work out some of the rules for how to reconstruct the brain. We can now make thousands of predictions that when tested are accurate, and we can reconstruct small brain circuits of up to about 1 million rat neurons. Now we've got to connect those groups of neurons to make brain regions, then connect the regions to make a computer model of a whole brain. Once we've modelled a rat brain, then we update the rules and gradually move towards a human model.

Could the model be too detailed?
People are afraid of detail and complexity. But a drug is a molecule. It doesn't hit a cell, or the brain, it hits other molecules. There's no reason why we shouldn't try to explain how all the molecules are interacting with one another. Sheer numbers do not equal complexity. One hundred billion neurons is numbers, not complexity.

What about criticisms that it drains funds from more readily achievable neuroscience?
That is an incredibly short-sighted view of how a big science project impacts the rest of the field. Take the Human Genome Project - you can criticise them for all the promises they made at the time, but we would be in the dark ages now if we hadn't done that project. It has benefitted every biologist and geneticist on the planet today.

Once completed, could the simulated brain ever become conscious?
When we couple the model to a robot, the robot will behave, and we'll see this in the way its neurons are firing. Does that mean it's conscious? That's a philosophical question - and an unresolved one.

This article appeared in print under the headline "One minute with... Henry Markram"

Profile

Henry Markram is the director of the Human Brain Project at the Swiss Federal Institute of Technology in Lausanne (EPFL). The project just won a €1 billion European research prize

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