Why we're building a €1 billion model of a human brain

The Human Brain Project has just won a €1 billion research prize. Its director Henry Markram says the initiative will unify our understanding of the brain

Your project aims to recreate the human brain in a supercomputer. Why?
We want to reach a unified understanding of the brain and the simulation on a supercomputer is the tool. Today you have neuroscientists working on a genetic, behavioural or cognitive level, and then you have informaticians, chemists and mathematicians. They all have their own understanding of how the brain functions and is structured. How do you get them all around the same table? We think of the project as like a CERN for the brain. The model is our way of bringing everyone, and our understanding, together.

What do you hope will come of the project?
There are three goals. As the model becomes more accurate and behaves more like a brain, we could couple it to a robot and see the robot learning. Then we'll be able to trace the chain of events from molecules to cognition.

Second, we plan to collect data from hospitals around the world to search for biological signatures of disease. We believe this will give us a new classification of brain disease, which can be used to diagnose people objectively - not solely based on their symptoms.

And finally, we want to build neuromorphic computers, which would have processors that can learn, mimicking the way the brain does.

How close are you to recreating a brain?
We've developed an algorithm to work out some of the rules for how to reconstruct the brain. We can now make thousands of predictions that when tested are accurate, and we can reconstruct small brain circuits of up to about 1 million rat neurons. Now we've got to connect those groups of neurons to make brain regions, then connect the regions to make a computer model of a whole brain. Once we've modelled a rat brain, then we update the rules and gradually move towards a human model.

Could the model be too detailed?
People are afraid of detail and complexity. But a drug is a molecule. It doesn't hit a cell, or the brain, it hits other molecules. There's no reason why we shouldn't try to explain how all the molecules are interacting with one another. Sheer numbers do not equal complexity. One hundred billion neurons is numbers, not complexity.

What about criticisms that it drains funds from more readily achievable neuroscience?
That is an incredibly short-sighted view of how a big science project impacts the rest of the field. Take the Human Genome Project - you can criticise them for all the promises they made at the time, but we would be in the dark ages now if we hadn't done that project. It has benefitted every biologist and geneticist on the planet today.

Once completed, could the simulated brain ever become conscious?
When we couple the model to a robot, the robot will behave, and we'll see this in the way its neurons are firing. Does that mean it's conscious? That's a philosophical question - and an unresolved one.

This article appeared in print under the headline "One minute with... Henry Markram"

Profile

Henry Markram is the director of the Human Brain Project at the Swiss Federal Institute of Technology in Lausanne (EPFL). The project just won a €1 billion European research prize

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Philippines' Aquino visits rebel stronghold

SULTAN KUDARAT, Philippines: Philippine President Benigno Aquino paid a historic visit Monday to Muslim rebel territory in a bid to speed up efforts to end one of Asia's longest and deadliest insurgencies.

Four months after his government agreed on a roadmap with the Moro Islamic Liberation Front for a final peace deal by 2016, Aquino travelled to the insurgents' stronghold in the far south as a confidence-building measure.

"We have just three years and four months left. We have to speed up everything we are doing now to make this (peace) permanent," Aquino said on a stage alongside MILF chief Murad Ebrahim just outside the rebels' main base.

The deadline for peace coincides with the end of Aquino's six-year term as president. The constitution limits him to one term and there are concerns that the next president may not be able, or may not want, to pursue the peace agenda.

The 12,000-strong MILF has been fighting since the 1970s for independence in Mindanao, the southern third of the mainly Catholic Philippines that the country's Muslim minority claim as their ancestral homeland.

An estimated 150,000 people have died in the conflict with Muslim rebels, although a ceasefire in place since 2003 has largely held.

In the "framework agreement" signed last October, the MILF said it would give up its quest for independence in exchange for significant power and wealth-sharing in a new autonomous region covering large parts of Mindanao.

Many of the toughest details have yet to be agreed, and there have been no major breakthroughs in ensuing negotiations between the two sides.

However Aquino expressed confidence that the negotiations would yield significant results within weeks, and that a final peace pact could be achieved by 2016.

"We're very close to agreements on all the points," he said.

The key event on Monday, held just outside the MILF's heavily fortified Camp Darapanan, was the launch of joint development projects seen by both sides as crucial to the peace process.

It was the first peace mission by a president to the MILF's powerbase.

Then-president Joseph Estrada travelled to the area in 2000 but only at a time of heavy fighting, shortly after government troops overran another base that was then the rebels' main camp.

Estrada infamously brought pork and beer to the Muslim areas so government troops could celebrate their victory.

Speaking at Monday's event, Murad said Aquino's trip was a highly symbolic and important boost to the peace process.

"Truly we are humbled by this grand gesture of the president of personally launching several socio-economic projects... on this hallowed ground which has seen many of the battles we have fought," he said.

Murad emphasised the need to bring prosperity to Mindanao, a fertile and resource-rich region that remains one of the country's poorest areas because of the conflict as well as corruption.

"Development is so important... this goal must therefore be the single most important task of this partnership," he said.

The programmes launched on Monday involve education scholarships, expanded health networks and job creation projects.

After the launch of the development projects, Aquino travelled to a military camp to watch a game of football between MILF fighters and government soldiers.

-AFP/ac

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'Within seconds, everything changed'

By Dana Ford, CNN

updated 12:26 AM EST, Mon February 11, 2013

STORY HIGHLIGHTS

• NEW: Mississippi Gov. Phil Bryant declares a state of emergency in four counties


• At least a dozen people are injured; no deaths are reported


• "Within seconds, everything changed," says a Hattiesburg, Mississippi resident

iReport: Please send your photos and videos, but stay safe

(CNN) -- A tornado touched down in southern Mississippi on Sunday, injuring more than a dozen people and causing widespread damage.

So far, no one has been reported killed, which authorities hope will remain true.

"We're really blessed because we don't have a fatality that we know of right now, and no major injuries. But we have a number of major damages to our structures around town," said Johnny DuPree, mayor of Hattiesburg, where the tornado hit.

"If there is a good thing about this, it happened on a Sunday when most of these structures were vacant," he said.

Mississippi Gov. Phil Bryant declared a state of emergency in four counties: Forrest, Lamar, Lawrence and Marion.

iReporter shopping at Target captures video of tornado

Hattiesburg, which straddles Forrest and Lamar counties, is home to the University of Southern Mississippi. It suffered damage to several buildings, but there were no reports of injuries there. University police declared a state of emergency and urged those not on campus to stay away until further notice.

Nearby Oak Grove High School also suffered damage. Randy Wright posted photographs to his Twitter account of the school, showing debris strewn on what looked to be a parking lot and a truck upside down in a baseball diamond.

The Hattiesburg Public School District canceled classes Monday. The university campus will also be closed.

"There's quite a few homes without power at this point. Quite a few trees on houses, on cars, that type of thing," said Forrest County Sheriff Billy McGee.

He said that from 10 to 15 people were taken to the hospital, but that none suffered serious injuries. Another three were reported injured in nearby Marion County.

It was not clear how those people were hurt.

Sarah Lawrence, a Hattiesburg resident, said that the storm sounded like "stuff being thrown."

"Within seconds, everything changed," she said. "I didn't feel like there was much notice. I heard the sirens and everything looked OK outside, so I started making preparations to go into the bathroom. And then, next thing I know, all the lights went out, and it got dark outside."

As the storm system moved east Sunday night, tornado warnings were issued -- then expired -- for parts of southeastern Mississippi and southwestern Alabama.

Northeast begins digging out from major blizzard

The 10 deadliest U.S. tornadoes on record

23 incredible weather photos

CNN's Maggie Schneider, Elwyn Lopez and Janet DiGiacomo contributed to this report.

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New Englanders slowly recover from weekend blizzard

NEWPORT, R.I. Travel eased and life slowly returned to normal for most New Englanders after a massive blizzard, but many remained without power in cold and darkened homes and a forecast of rain brought a new worry: Weight piling up dangerously on roofs already burdened by heavy snow.

61 Photos

Powerful blizzard descends on Northeast

Play Video

Northeast sees record snow fall

The storm that slammed into the region with up to 3 feet of snow was blamed for at least 14 deaths in the Northeast and Canada, and brought some of the highest accumulations ever recorded. Still, coastal areas were largely spared catastrophic damage despite being lashed by strong waves and hurricane-force wind gusts at the height of the storm.

President Barack Obama declared a state of emergency for Connecticut, allowing federal aid to be used in recovery, and utilities in some hard-hit New England states predicted that the storm could leave some customers in the dark for days.

CBS News correspondent Miguel Bojorquez reports that Hamden, Conn., about 80 miles from New York City, experienced the deepest snow: 40 inches. The blizzard had dumped five inches of snow per hour.

Hundreds of people, their homes without heat or electricity, were forced to take refuge in emergency shelters set up in schools or other places.

"For all the complaining everyone does, people really came through," said Rich Dinsmore, 65, of Newport, R.I., who was staying at a Red Cross shelter set up in a middle school in Middletown after the power went out in his home on Friday.

Dinsmore, who has emphysema, was first brought by ambulance to a hospital after the medical equipment he relies on failed when the power went out and he had difficulty breathing.

"The police, the fire department, the state, the Red Cross, the volunteers, it really worked well," said the retired radio broadcaster and Army veteran.

Utility crews, some brought in from as far away as Georgia, Oklahoma and Quebec, raced to restore power to more than 300,000 customers -- down from 650,000 in eight states at the height of the storm. In hardest-hit Massachusetts, where some 234,000 customers remained without power on Sunday, officials said some of the outages might linger until Tuesday.

Driving bans were lifted and flights resumed at major airports in the region that had closed during the storm, though many flights were still canceled Sunday.

Boston recorded 24.9 inches of snow, making it the fifth-largest storm in the city since records were kept.

On eastern Long Island, which was slammed with as much as 30 inches of snow, hundreds of snowplows and other heavy equipment were sent in Sunday to clear ice- and drift-covered highways where hundreds of people and cars were abandoned during the height of the storm.

More than a third of all the state's snow-removal equipment was sent to the area, Gov. Andrew Cuomo said, including more than 400 plow trucks and more than 100 snow blowers, loaders and backhoes.

Play Video

Snow leaves Long Island Expressway commuters stranded

Play Video

Mass. town powerless after record snow storm

The National Weather Service was forecasting rain and warmer temperatures in the region on Monday -- which could begin melting some snow but also add considerable weight to snow already piled on roofs, posing the danger of collapse. Of greatest concern were flat or gently-sloped roofs and officials said people should try to clear them -- but only if they could do so safely.

"We don't recommend that people, unless they're young and experienced, go up on roofs," said Peter Judge, spokesman for the Massachusetts Emergency Management Agency.

Officials also continued to warn of carbon monoxide dangers in the wake of the storm.

In Boston, two people died Saturday after being overcome by carbon monoxide while sitting in running cars, including a teenager who went into the family car to stay warm while his father shoveled snow. The boy's name was not made public. In a third incident, two children were hospitalized but expected to recover.

A fire department spokesman said in each case, the tailpipes of the cars were clogged by snow.

Authorities also reminded homeowners to clear snow from heating vents to prevent carbon monoxide from seeping back into houses.

In Maine, the Penobscot County Sheriff's office said it recovered the body of a 75-year-old man who died after the pickup he was driving struck a tree and plunged into the Penobscot River during the storm. Investigators said Gerald Crommett apparently became disoriented while driving in the blinding snow.

Christopher Mahood, 23, of Germantown, N.Y., died after his tractor went off his driveway while he was plowing snow Friday night and rolled down a 15-foot embankment.

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Possible Dorner Sighting Leads to Store Evacuation

A Northridge, Calif., home improvement store was evacuated tonight because of a possible sighting of suspected cop-killer Christopher Dorner, just hours after police announced a $1 million reward for information leading to his arrest.

As helicopters hovered overhead and a command center was established, police searched the Lowe's store and eventually told shoppers they could leave, but could not take their cars out of the parking lot.

LAPD spokesman Gus Villanueva said the major response to the possible sighting was a precaution, but couldn't say whether Dorner was in the area.

The announcement of the $1 million reward today came as authorities in Big Bear, Calif., scaled back their search for Dorner, the disgruntled ex-cop who is suspected in three revenge killings.

"This is the largest local reward ever offered, to our knowledge," Los Angeles Police Chief Charlie Beck said at a news conference today. "This is an act of domestic terrorism. This is a man who has targeted those that we entrust to protect the public. His actions cannot go unanswered."

The money for the reward was pooled by businesses, government, local law enforcement leaders and individual donors, Beck said.

PHOTOS: Former LAPD Officer Suspected in Shootings

The reward comes on the fourth day of a manhunt for Dorner, who has left Southern California on edge after he allegedly went on a killing spree last week to avenge his firing from the police force. Dorner outlined his grievances in a 6,000 word so-called "manifesto" and said he will keep killing until the truth is known about his case.

Irvine Police Department/AP Photo

Manhunt for Alleged Cop Killer Heads to California Mountains Watch Video

Christopher Dorner Search: Officials Search for Ex-officer in the Mountains Watch Video

Dorner's threats have prompted the LAPD to provide more than 50 law enforcement families with security and surveillance detail, Beck said.

Authorities are chasing leads, however they declined to say where in order to not impede the investigation.

Dorner's burned-out truck was found Thursday near Big Bear Lake, a popular skiing destination located 80 miles northeast of Los Angeles.

Investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned, sources told ABC News.

The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.

Full Coverage: Christopher Jordan Dorner

Officers have spent the past couple of days going door-to-door and searching vacant cabins. The manhunt was scaled back to 25 officers and one helicopter in the resort town today, according to the San Bernadino Sheriff's Office.

On Saturday, Beck announced he would reopen the investigation into Dorner's firing but said the decision was not made to "appease" the fugitive ex-cop.

"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," Beck said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint."

Dorner is suspected of killing Monica Quan and her fiancé Keith Lawrence last Sunday in their car in the parking lot of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.

Quan's father, Randal Quan, was a retired captain with the LAPD and attorney who represented Dorner before a police review board that led to Dorner's dismissal from the force in 2008.

On Wednesday, after Dorner was identified as a suspect in the double murder, police believe he ambushed two Riverside police officers, killing one and wounding the other.

The next day, Randal Quan reported he received a taunting call from a man claiming to be Dorner who told him that he "should have done a better job of protecting his daughter," according to court documents documents.

Anyone with information leading to the arrest of Christopher Dorner is asked to call the LAPD task force at 213-486-6860.

ABC News' Dean Schabner, Jack Date, Pierre Thomas, Jason Ryan and Clayton Sandell and The Associated Press contributed to this report.

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Time to rinse! AI assistant helps clean your teeth

FOR most of us, brushing our teeth is just a tedious part of the daily grind. But for people with dementia or learning difficulties, such tasks can be difficult. They could soon gain more independence thanks to an AI designed by Christian Peters at Bielefeld University in Germany and his colleagues.

Peters has already come up with a system that guides people when washing their hands. Brushing teeth is more complicated because it involves many steps - such as putting toothpaste on the brush, filling a glass with water or rinsing the mouth.

The TEBRA system uses a video camera to monitor someone brushing their teeth and checks that each step happens at the right time. It prompts them via a screen on the washstand if they forget a step or if they get stuck. The idea is not to dictate a routine, but to adapt to that of the user, says Peters.

TEBRA is being tested at a care home in Bielefeld for people with learning disabilities. Caregivers there reported that the system was less distracting for some people than a human carer. The work will be presented at the International Conference on Health Informatics in Barcelona, Spain, next week. Peters also plans to adapt his system to tasks such as shaving.

This article appeared in print under the headline "Time to rinse! An AI to help you clean your teeth"

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Man arrested for allegedly molesting women on public bus

SINGAPORE: Police have arrested a man for allegedly outraging the modesty of two women on a public bus.

The 29-year-old suspect was nabbed at about 2:45pm on Saturday.

His victims, aged 21 and 35, were molested on separate occasions on board the same bus, in the vicinity of Ang Mo Kio Avenue 5.

Upon being alerted of the incidents, the bus captain immediately stopped his vehicle and closed the doors to prevent the suspect from escaping.

Officers from Ang Mo Kio Police Division soon arrived and placed the suspect under arrest.

The man will be charged in court on Monday.

If convicted he could be jailed up to two years and caned.

- CNA/ck

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Almost famous: See celebs' early roles

By Henry Hanks, CNN

updated 5:05 PM EST, Thu February 7, 2013

Stars who started out like GoDaddy's geek

Jesse Heiman

Sylvester Stallone

John Travolta

Keanu Reeves

Courtney Cox

Matt LeBlanc

Tina Fey

Rainn Wilson

Megan Fox

Dean Winters

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LAPD Reopens Case of Suspected Cop-Killer's Firing

The Los Angeles Police Department announced today it will reopen the case of the firing of Christopher Dorner, but said the decision was not made to "appease" the fugitive former cop suspected of killing three people.

Dorner, a fired and disgruntled former Los Angeles police officer, said in the so-called "manifesto" he released that he was targeting LAPD officials and their families and will keep killing until the truth is known about his case.

"I have no doubt that the law enforcement community will bring to an end the reign of terror perpetrated on our region by Christopher Jordan Dorner and he will be held accountable for his evil actions," LAPD Chief Charlie Beck said in a statement released tonight.

He spoke of the "tremendous strides" the LAPD has made in regaining public trust after numerous scandals, but added: "I am aware of the ghosts of the LAPD's past and one of my biggest concerns is that they will be resurrected by Dorner's allegations of racism within the Department."

To do that, he said, full re-investigation of the case that led to Dorner's firing is necessary.

"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," he said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint.

Irvine Police Department/AP Photo

Christopher Dorner Search: Officials Search for Ex-officer in the Mountains Watch Video

Hundreds of Officers on Hunt for Alleged Cop Killer Watch Video

"I do this not to appease a murderer. I do it to reassure the public that their police department is transparent and fair in all the things we do."

PHOTOS: Former LAPD Officer Suspected in Shootings

As police searched for Dorner today in the San Bernardino Mountains, sources told ABC News that investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned.

The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.

A man identifying himself as Dorner taunted the father of Monica Quan four days after the former LAPD officer allegedly killed her and just 11 hours after he allegedly killed a police officer in Riverside, Calif., according to court documents obtained by ABC News

A man claiming to be Dorner called Randall Quan and told him that that he "should have done a better job of protecting his daughter," according to the documents.

In his 6,000-word "manifesto," Dorner named Randal Quan, a retired LAPD captain and attorney who represented him before a police review board that led to Dorner's dismissal from the force.

"I never had an opportunity to have a family of my own, I'm terminating yours," Dorner wrote, and directed Quan and other officials to "[l]ook your wives/husbands and surviving children directly in the face and tell them the truth as to why your children are dead."

Monica Quan and her fiancé Keith Lawrence were gunned down last Sunday in their car in the parking of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.

The call, according to court records, was traced to Vancouver, Wash., but law enforcement officials do not believe Dorner was there at the time at the call.

Dorner is believed to have made the call early Thursday afternoon, less than half a day after he is suspected of killing a police officer and wounding two others early that morning, sparking an unprecedented man hunt involving more than a thousand police officers and federal agents spanning hundreds of miles.

FULL COVERAGE: Christopher Jordan Dorner

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Crowds prowl Google Street View to speed road repairs

POTHOLES, cracks, gnarly tree roots - the streets are full of nasty obstacles when they fall into disrepair. But an army of online workers could soon fix that, by whizzing virtually through neighbourhoods and earmarking encumbrances for a quick response from the local council.

Jon Froehlich and colleagues at the University of Maryland in College Park have developed software that allows untrained crowdsourced workers from Amazon's Mechanical Turk service (AMT) to zoom through the streets using Google Street View and find and label the potholes, obstructed pathways, broken kerbs and missing ramps that can stymie street access, particularly for those using a wheelchair or a walking aid. A report that includes images of highlighted problem areas can then be generated for the local council's road-mending crews to act on.

The researchers built a prototype following interest in the idea from officials at the US Department of Transportation, who said that the project could save municipalities precious time and resources by telling repair teams the precise nature of the problem before they head into the field. This would aid scheduling and ensure that crews take the right amount of materials - such as concrete or flagstones - to the site.

The team tested the labelling software using six volunteers - three members of the research team and three wheelchair users - and then set the task to 400 AMT workers. After viewing a short instructional video, which showed how to identify problem areas by labelling them with coloured shapes, the workers accurately spotted access issues 93 per cent of the time. Froehlich will present the work in April at the Conference on Human Factors in Computing Systems in Paris, France.

In the next version of the system, the team wants to automate the process using computer vision algorithms. The researchers also hope to access the precise laser range-finding data that the Street View camera cars acquire as they comb the streets. Such information would increase accuracy when assessing the sizes and shapes of obstructions.

"It sounds like this project has a lot of parallels with FixMyStreet," says Myfanwy Nixon of mySociety, a non-profit organisation in London that runs FixMyStreet.com, where people can report street problems. "Online technologies are very good for people with limited mobility or a disability that prevents them from getting their voice out via other means."

This article appeared in print under the headline "Online eyes see the way to an easier amble"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

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